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After four straight losses to San Francisco, including two in the postseason, Green Bay may be ready to take out some frustrations in the Packers-49ers game Sunday. And the way the past two weeks have played out for San Francisco, the 49ers may be unable to do much to prevent it, even at home.

FOX will televise the Packers and 49ers at 4:25 p.m. Eastern Sunday from Levi Stadium in Week 4 of the NFL season.

After looking very strong in a 20-3 Week 1 win at home against Minnesota, San Francisco collapsed in back to back road games, losing to Pittsburgh and Arizona by a combined 90-25.

Heading into the Packers-49ers game, San Franciscos Colin Kaepernick will be coming off of one of his worst games as a pro quarterback in a 47-7 loss at Arizona. Kaepernick completed just 9 of 19 passes for 67 yards with four interceptions. He did rush for 46 yards and a touchdown against the Cardinals, but it was nowhere near enough to keep the game competitive.

The frustration level for Green Bay fans when involved in a Packers-49ers game is extremely high, as San Francisco has found a variety of ways to upend the Packers in key games recently.

This will be the first Packers-49ers contest since the 2013 NFC playoffs, when San Francisco went to Lambeau Field and upset Green Bay, 23-20, in the Wild Card round, kicking a field goal as time expired.

The Packers and 49ers last played in the regular season during the 2013 campaign, when San Francisco won at home, 34-28, behind 412 passing yards from Kaepernick, which represents his career high mark.

San Francisco also won twice in the Packers-49ers series during the 2012 season. The Niners won at Green Bay, 30-22, to open the 2012 regular season. Then, with Kaepernick inserted as the starting quarterback for the playoffs, he had an NFL playoff quarterback rushing record of 181 yards as the Packers and 49ers played in San Francisco in the Divisional Round, with the Niners winning, 45-31.

Green Bay last won a Packers-49ers game during the 2010 regular season at Lambeau Field, 34-16. Green Bay quarterback Aaron Rodgers had 298 yards throwing in that game, including three touchdowns.

Green Bay leads the all-time Packers-49ers series, 30-27-1, including a 4-3 record against San Francisco in the postseason. Before San Franciscos recent four-game winning streak against the Packers, the 49ers had lost eight straight in the series.